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. 2009 Mar 23;14(3):1227-33.
doi: 10.3390/molecules14031227.

Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis

Mat Ropi Mukhtar  1 , Ahmad Nazif Aziz, Noel F Thomas, A Hamid A Hadi, Marc Litaudon, Khalijah Awang
Affiliations

Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis

Mat Ropi Mukhtar et al. Molecules. .

Abstract

The stem bark of Phoebe grandis afforded one new oxoproaporphine; (-)-grandine A (1), along with six known isoquinoline alkaloids: (-)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR data of the tetrahydroproaporphine (-)-8,9-dihydrolinearisine (2) is also reported. The alkaloids' structures were elucidated primarily by means of high field 1D- and 2D-NMR and HRMS spectral data.

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Figures

Figure 1
Figure 1
Structures of (+) –grandine A 1, (-)-8,9-dihydrolinearisine 2, (+)-scortechiniine B 3 and prooxocryptochine 4.
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