Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Mar 26;458(7237):430-7.
doi: 10.1038/nature07959.

Ubiquitylation in innate and adaptive immunity

Vijay G Bhoj  1 , Zhijian J Chen
Affiliations
Review

Ubiquitylation in innate and adaptive immunity

Vijay G Bhoj et al. Nature. .

Abstract

Protein ubiquitylation has emerged as a key mechanism that regulates immune responses. Much like phosphorylation, ubiquitylation is a reversible covalent modification that regulates the stability, activity and localization of target proteins. As such, ubiquitylation regulates the development of the immune system and many phases of the immune response, including its initiation, propagation and termination. Recent work has shown that several ubiquitin ligases help to prevent the immune system from attacking self tissues. The dysfunction of several ubiquitin ligases has been linked to autoimmune diseases.

PubMed Disclaimer

References

    1. Int Immunol. 2006 Oct;18(10):1405-11 - PubMed
    1. Mol Cell. 2008 Jun 20;30(6):689-700 - PubMed
    1. J Exp Med. 2004 Jan 19;199(2):167-72 - PubMed
    1. Cell. 2006 Feb 10;124(3):601-13 - PubMed
    1. Cancer Cell. 2007 Nov;12(5):445-56 - PubMed

Publication types