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Review
. 2009 Mar 26;458(7237):461-7.
doi: 10.1038/nature07963.

Principles of ubiquitin and SUMO modifications in DNA repair

Steven Bergink  1 , Stefan Jentsch
Affiliations
Review

Principles of ubiquitin and SUMO modifications in DNA repair

Steven Bergink et al. Nature. .

Abstract

With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.

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