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. 2008 Jan;9(1):56-64.
doi: 10.3390/ijms9010056. Epub 2008 Jan 21.

Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Ewelina Szliszka  1 , Zenon P Czuba  1 , Katarzyna Jernas  1 , Wojciech Król  1
Affiliations

Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Ewelina Szliszka et al. Int J Mol Sci. 2008 Jan.

Abstract

TRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in combination with TRAIL on HeLa cells. It was found that treatment with noncytotoxic concentration of some flavonoids significantly sensititizes to TRAIL induced death in HeLa cells. Our study demonstrated that flavone, apigenin and genistein markedly augmented TRAIL mediated cytotoxicity against HeLa, whereas kaempferol and quercetin produced no effect.

Keywords: Dietary flavonoids; HeLa; TRAIL; antitumoral activity; chemoprevention.

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Figures

Figure 1.
Figure 1.
The apoptotic effecs of flavonoids and flavonoids with TRAIL on HeLa cells. Concentration of flavonoids – 50μM. The results of studies are expressed as mean values ± SD from three separate experiments. * – P<0.05, ** - P<0.01 versus a respective control.
See this image and copyright information in PMC

References

    1. Havesteen B. The Flavonoids, a class of natural products oh high pharmacological potency. Biochem Pharmacol. 1983;32:1141–1148. DOI 10.1016/0006-2952(83)90262-9; PubMed 6342623. - PubMed
    1. Middleton E. The Flavonoids. TIPS. 1984;5:335–338.
    1. Middleton E, Kandaswami C, Theoharides TC. The effect of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev. 2000;52:673–751. PubMed 11121513. - PubMed
    1. Kanadaswami C, Lee LT, Lee PP, Hwang JJ, Ke FC, Huang YT, Lee MT. The antitumor activities of flavonoids. In Vivo. 2005;19:895–909. PubMed 16097445. - PubMed
    1. Thomasset SC, Berry DP, Garcea G, Marczylo T, Steward WP, Gescher AJ. Dietary polyphenolic phytochemicals - promising cancer chemopreventive agents in humans? A review of their clinical properties. Int J Cancer. 2007;120:451–458. DOI 10.1002/ijc.22419; PubMed 17131309. - PubMed

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