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. 2009 Mar;5(3):e1000221.
doi: 10.1371/journal.ppat.1000221. Epub 2009 Mar 27.

New disturbing trend in antimicrobial resistance of gram-negative pathogens

Jung Hun Lee  1 , Seok Hoon Jeong, Sun-Shin Cha, Sang Hee Lee
Affiliations

New disturbing trend in antimicrobial resistance of gram-negative pathogens

Jung Hun Lee et al. PLoS Pathog. 2009 Mar.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Ribbon diagram of crystallographic structure of CMY-10 (a cESBL).
The image was rendered with PyMOL, available on the Internet (http://sourceforge.net/projects/pymol). The R2-loop is represented as red, while the Ω-loop, H-2 helix, and H-11 helix are depicted in violet, blue, and cyan, respectively. The R1 active site (central upper region) is surrounded by the Ω-loop and the R2 active site (central lower region) by the R2-loop and H-11 helix. The nucleophile (Ser65), attacking the carbonyl carbon of β-lactam ring, is present in the H-2 helix.
See this image and copyright information in PMC

References

    1. Chopra I, Schofield C, Everett M, O'Neill A, Miller K, et al. Treatment of health-care-associated infections caused by Gram-negative bacteria: A consensus statement. Lancet Infect Dis. 2008;8:133–139. - PubMed
    1. Thomson JM, Bonomo RA. The threat of antibiotic resistance in Gram-negative pathogenic bacteria: Beta-lactams in peril! Curr Opin Microbiol. 2005;8:518–524. - PubMed
    1. Kim C, Hesek D, Zajicek J, Vakulenko SB, Mobashery S. Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3″)-Ii/AAC(6′)-IId from Serratia marcescens. Biochemistry. 2006;45:8368–8377. - PubMed
    1. Robicsek A, Strahilevitz J, Jacoby GA, Macielag M, Abbanat D, et al. Fluoroquinolone-modifying enzyme: A new adaptation of a common aminoglycoside acetyltransferase. Nat Med. 2006;12:83–88. - PubMed
    1. Yamane K, Wachino J, Suzuki S, Kimura K, Shibata N, et al. Novel plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob Agents Chemother. 2007;51:3354–3360. - PMC - PubMed

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