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Comment
. 2009 Mar 27;33(6):669-70.
doi: 10.1016/j.molcel.2009.03.002.

Intricate links between ER stress and apoptosis

Frank Madeo  1 , Guido Kroemer
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Free article
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Intricate links between ER stress and apoptosis

Frank Madeo et al. Mol Cell. .
Free article

Abstract

Bax inhibitor-1 (BI-1) interacts with Bax, neutralizing its proapoptotic activity. In this issue of Molecular Cell, Lisbona et al. (2009) show that BI-1 directly inhibits IRE1alpha, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.

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