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. 2009 Sep;67(9):1550-8.
doi: 10.1016/j.apradiso.2009.02.091. Epub 2009 Mar 9.

99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer--in vitro and in vivo results

G M M Gommans  1 , E Gommans, F M van der Zant, G J J Teule, T G van der Schors, J W D de Waard
Affiliations

99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer--in vitro and in vivo results

G M M Gommans et al. Appl Radiat Isot. 2009 Sep.

Abstract

This study evaluated labelling efficiency and radiochemical purity of (99m)Tc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of (99m)Tc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2h eluate in vacuum or nitrogen. Labelling 26 MBq/microg (99m)Tc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.

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