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. 2008 Nov;9(11):2169-2183.
doi: 10.3390/ijms9112169. Epub 2008 Nov 7.

Survey of slaughtered pigs for occurrence of ochratoxin A and porcine nephropathy in Serbia

Dragan Milićević  1 , Verica Jurić  2 , Srđan Stefanović  1 , Milijan Jovanović  3 , Saša Janković  1
Affiliations

Survey of slaughtered pigs for occurrence of ochratoxin A and porcine nephropathy in Serbia

Dragan Milićević et al. Int J Mol Sci. 2008 Nov.

Abstract

Samples of blood, kidney and liver were randomly selected from slaughtered pigs (n=90) and analyzed for ochratoxin A by HPLC. In addition, in order to obtain information on the occurrence of nephropathy, histological examinations were carried out. Of the 90 liver samples, 26.6% contained OTA in the range of 0.22-14.5 ng/g. The incidence of OTA in serum and kidney were very similar (31%, 33.3%), with a maximum concentration of 220.8 ng/mL, and 52.5 ng/g, respectively. Histopathological examination of kidneys confirmed tubulopathies with edema and cell vacuolization. In addition, hemorrhages and necrosis of proximal kidney tubules' cells were found.

Keywords: Ochratoxin A; nephropathy; pig; tissues.

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Figures

Figure 1.
Figure 1.
External surface of a case of “mottled enlarged kidneys” (A) (second and fifth kidney dorsal aspect), and (B) normal sized kidneys, except for the third.
Figure 2.
Figure 2.
Summary of histological findings (PH) of renal tissues and incidence of OTA in kidney from slaughtered pigs (n=90). Necrosis of proximal tubules’ cells (1), hypercellularity of vascular loop (2), vascular changes (3), exudat in Bowman’s space (4), focal interstitial nephritis (5), dystrophy of proximal tubules’ cells (6), swelling of proximal tubules’ cells (7), renal hemorrhages (8), fatty changes of proximal tubules’ cells (9).
Figure 3.
Figure 3.
Dystrophy and vacuolar degeneration in the epithelium of proximal tubules’ cells (A), focal interstitial fibrosis (B), necrosis of proximal tubules’ cells (C) and hemorrhages in cortex (D).
See this image and copyright information in PMC

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