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Review
. 2009 Apr;4(4):444-7.
doi: 10.1097/JTO.0b013e31819d6f91.

MET pathway as a therapeutic target

Eric S Kim  1 , Ravi Salgia
Affiliations
Review

MET pathway as a therapeutic target

Eric S Kim et al. J Thorac Oncol. 2009 Apr.

Abstract

Dysregulation of mesenchymal-epithelial transition factor receptor tyrosine kinase pathway leads to cell proliferation, protection from apoptosis, angiogenesis, invasion, and metastasis. It can be dysregulated through overexpression, constitutive activation, gene amplification, ligand-dependent activation or mutation. New drugs targeting various mesenchymal-epithelial transition factor pathways are being investigated with promising results.

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Figures

Figure 1
Figure 1. MET Structure and Pathway
HGF (hepatocyte growth factor); SEMA (Semaphorin-like); PSI (found in Plexins, Semaphorins, and Integrins); IPT (found in Ig-like regions, Plexins and Transcription factors); TM (Trans-Membrane); JM (Juxta-Membrane); TK (Intracellular Tyrosine Kinase); SOS (son of sevenless); GRB2 (growth factor receptor-bound protein 2); GAB1 (GRB2-associated binding protein 1); PI3K (phosphoinositol 3 kinase); PLCγ (phospholipase C γ).
See this image and copyright information in PMC

References

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    1. Sattler M, Salgia R. c-Met and hepatocyte growth factor: potential as novel targets in cancer therapy. Curr Oncol Rep. 2007;9:102–108. - PubMed

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