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. 1991 Jul 19;554(1-2):352-4.
doi: 10.1016/0006-8993(91)90216-i.

Brain corticotropin-releasing hormone increases arousal in stress

T Shibasaki  1 , N Yamauchi, M Hotta, T Imaki, T Oda, N Ling, H Demura
Affiliations

Brain corticotropin-releasing hormone increases arousal in stress

T Shibasaki et al. Brain Res. .

Abstract

The effect of restraint stress on pentobarbital-induced sleeping time was examined in rats. Restraint for 60 and 75 min significantly shortened pentobarbital-induced sleeping time. The shortening of sleeping time by restraint was completely reversed by intracerebroventricular (i.c.v.) administration of alpha-helical CRH(9-41), a corticotropin-releasing hormone (CRH) receptor antagonist. In conjunction with our previous finding that i.c.v. administration of CRH shortens pentobarbital-induced sleeping time, the results suggest that restraint stress increases arousal through brain CRH.

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