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Review
. 2009 Jan;10(1):366-384.
doi: 10.3390/ijms10010366. Epub 2009 Jan 23.

The importance of brain banks for molecular neuropathological research: The New South Wales Tissue Resource Centre experience

Irina Dedova  1   2 , Antony Harding  2 , Donna Sheedy  2 , Therese Garrick  2 , Nina Sundqvist  1   2 , Clare Hunt  2 , Juliette Gillies  1   2 , Clive G Harper  2
Affiliations
Review

The importance of brain banks for molecular neuropathological research: The New South Wales Tissue Resource Centre experience

Irina Dedova et al. Int J Mol Sci. 2009 Jan.

Abstract

New developments in molecular neuropathology have evoked increased demands for postmortem human brain tissue. The New South Wales Tissue Resource Centre (TRC) at The University of Sydney has grown from a small tissue collection into one of the leading international brain banking facilities, which operates with best practice and quality control protocols. The focus of this tissue collection is on schizophrenia and allied disorders, alcohol use disorders and controls. This review highlights changes in TRC operational procedures dictated by modern neuroscience, and provides examples of applications of modern molecular techniques to study the neuropathogenesis of many different brain disorders.

Keywords: Human; alcohol; brain bank; clinical characterization; genome; molecular neuropathology; postmortem; proteome; receptor binding; schizophrenia.

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Figures

Figure 1.
Figure 1.
A flow-chart of the tissue request process at the TRC. Colors represent different domains in the request process: green – a researcher’s domain; yellow – the TRC domain; blue – a successful tissue request; and red – an unsuccessful tissue request.
See this image and copyright information in PMC

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