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. 2009 Apr 21:(15):2044-6.
doi: 10.1039/b823184b. Epub 2009 Feb 26.

Asymmetric generation of fluorine-containing quaternary carbons adjacent to tertiary stereocenters: uses of fluorinated methines as nucleophiles

Xiao Han  1 , Jie Luo, Chen Liu, Yixin Lu
Affiliations

Asymmetric generation of fluorine-containing quaternary carbons adjacent to tertiary stereocenters: uses of fluorinated methines as nucleophiles

Xiao Han et al. Chem Commun (Camb). .

Abstract

Organocatalytic asymmetric Michael reactions of fluorinated nucleophiles with nitroolefins catalyzed by Cinchona alkaloid-derived thiourea catalysts generated the desired Michael products containing vicinal fluorinated quaternary and tertiary chiral centers with exceptional enantioselectivity.

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