Review
Targeting TGFbeta-mediated processes in cancer
Affiliations
- PMID: 19333871
Item in Clipboard
Review
Targeting TGFbeta-mediated processes in cancer
Curr Opin Drug Discov Devel.
2009 Mar.
Abstract
TGFbeta is a pleiotropic cytokine that has regulatory roles during embryonic development and adult tissue homeostasis, and is especially important for epithelial, neural and immune system differentiation and function. An increasing number of literature reports support a role for autocrine and paracrine TGFbeta-mediated processes in cancer. Progress in delineating the effects of TGFbeta in different tumors and stages of cancer has stimulated the development of TGFbeta-targeted therapies. This review describes the causes of TGFbeta malfunction in cancer, the rationale for therapeutic targeting of TGFbeta in human neoplasia, and the molecular strategies to modulate the signal.
Similar articles
-
Escaping from the TGFbeta anti-proliferative control.Carcinogenesis. 2006 Nov;27(11):2148-56. doi: 10.1093/carcin/bgl068. Epub 2006 May 12. Carcinogenesis. 2006. PMID: 16698802 Review.
-
Development of TGF-beta signalling inhibitors for cancer therapy.Nat Rev Drug Discov. 2004 Dec;3(12):1011-22. doi: 10.1038/nrd1580. Nat Rev Drug Discov. 2004. PMID: 15573100 Review.
-
Inhibition of TGFβ signaling and its implications in anticancer treatments.Exp Oncol. 2012;34(1):9-16. Exp Oncol. 2012. PMID: 22453142 Review.
-
Roles of TGFbeta in metastasis.Cell Res. 2009 Jan;19(1):89-102. doi: 10.1038/cr.2008.316. Cell Res. 2009. PMID: 19050696 Review.
-
[Cellular signaling in response to TGFbeta: the paradox of a factor that blocks cell proliferation and enhances metastasis].Bull Cancer. 1999 Nov;86(11):903-10. Bull Cancer. 1999. PMID: 10586106 Review. French.
Cited by
-
FKBP51 increases the tumour-promoter potential of TGF-beta.Clin Transl Med. 2014 Jan 27;3(1):1. doi: 10.1186/2001-1326-3-1. Clin Transl Med. 2014. PMID: 24460977 Free PMC article.
-
Schlafen 3 induction by cyclic strain regulates intestinal epithelial differentiation.Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G994-G1003. doi: 10.1152/ajpgi.00517.2009. Epub 2010 Mar 18. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 20299602 Free PMC article.
-
Loss of Schlafen3 influences the expression levels of Schlafen family members in ileum, thymus, and spleen tissue.PeerJ. 2020 Jan 28;8:e8461. doi: 10.7717/peerj.8461. eCollection 2020. PeerJ. 2020. PMID: 32025381 Free PMC article.
-
A digest on the role of the tumor microenvironment in gastrointestinal cancers.Cancer Microenviron. 2010 Mar 7;3(1):167-76. doi: 10.1007/s12307-010-0040-9. Cancer Microenviron. 2010. PMID: 21209782 Free PMC article.