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Review
. 2009 Apr;94(4):454-9.
doi: 10.3324/haematol.2008.005157.

Therapy-related myeloid neoplasms

Richard A Larson  1
Affiliations
Review

Therapy-related myeloid neoplasms

Richard A Larson. Haematologica. 2009 Apr.

Abstract

Therapy-related myeloid neoplasm is the term recently proposed by the World Health Organization to cover the spectrum of malignant disorders previously described as therapy-related myelodysplastic syndrome or therapy-related acute myeloid leukemia. In this perspective article, Dr. Larson explores the important question of whether the poor prognosis of these conditions reflects t-MN per se or, rather, associated findings such as complex cytogenetics that are also seen, although less frequently, in de novo myeloid neoplasms. See related article on page 542.

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Figures

Figure 1.
Figure 1.
Decision tree for the management of therapy-related myeloid neoplasms.
See this image and copyright information in PMC

Comment on

References

    1. Godley LA, Larson RA. The syndrome of therapy-related myelodysplasia and myeloid leukemia. In: Bennett John M., editor. The Myelodysplastic Syndromes Pathobiology and Clinical Management. Marcel Dekker; New York: 2002. pp. 139–76.
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    1. Smith SM, Le Beau MM, Huo D, Karrison T, Sobecks RM, Anastasi J, et al. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood. 2003;102:43–52. - PubMed
    1. Vardiman JW, Arber DA, Brunning RD, Larson RA, Matutes E, Baumann I, Thiele J. Therapy-related myeloid neoplasms. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Fourth Ed. Lyon, France: IARC Press; 2008. pp. 127–9.

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