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Review
. 2009 Apr;16(2):100-7.
doi: 10.1177/107327480901600202.

Signaling networks associated with BCR-ABL-dependent transformation

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Free article
Review

Signaling networks associated with BCR-ABL-dependent transformation

Lori A Hazlehurst et al. Cancer Control. 2009 Apr.
Free article

Abstract

Background: The fusion protein BCR-ABL results in constitutive tyrosine kinase activity. It also affects downstream targets as well as the subcellular location of the normally tightly regulated Abl tyrosine kinase.

Methods: The authors review the current knowledge concerning the signaling networks associated with BCR-ABL-dependent transformation.

Results: Although BCR-ABL is considered a single genetic change, the dysregulated tyrosine kinase activates a network of signals that contributes to cytokine-independent growth, resistance to apoptosis, and genetic instability.

Conclusions: The effectiveness of BCR-ABL-dependent transformation of hematopoietic stem cells is due not to a single pathway but rather to the culmination of a network of signaling pathways.

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