Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008;3(4):397-401.
doi: 10.2147/ijn.s3259.

Treatment of lymphomatous and leukemic meningitis with liposomal encapsulated cytarabine

Melanie Kripp  1 , Ralf-Dieter Hofheinz
Affiliations
Review

Treatment of lymphomatous and leukemic meningitis with liposomal encapsulated cytarabine

Melanie Kripp et al. Int J Nanomedicine. 2008.

Abstract

Liposomal encapsulated cytarabine (DepoCyte, Mundipharma GmbH, Limburg/Lahn, Germany) is a slow-release formulation of conventional cytarabine. It is licensed for intrathecal use in patients with lymphomatous and leukemic meningitis. DepoCyte obtained superior response rates, improved patient quality of life and improved the time to neurological progression in a randomized albeit small clinical trial. In this review we briefly summarize the clinical data and discuss them in light of clinical problems and possible treatment scenarios.

Keywords: leukemic meningitis; liposomal cytarabine; lymphomatous meningitis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Aichberger KJ, Herndlhofer S, Agis H, et al. Liposomal cytarabine for treatment of myeloid central nervous system relapse in chronic myeloid leukaemia occurring during imatinib therapy. Eur J Clin Invest. 2007;37:808–13. - PubMed
    1. Anaclerico B, Bongarzoni V, Chierichini A, et al. Liposomal cytarabine in the central nervous system (CNS) prophylaxis of elderly patients with aggressive B-cell non-Hodgkin’s lymphoma (NHL) and undifferentiated acute leukemia (UAL): preliminary results of a single-center experience. ASH Annual Meeting Abstracts. 2006;108:4663.
    1. Angst MS, Drover DR. Pharmacology of drugs formulated with DepoFoam: a sustained release drug delivery system for parenteral administration using multivesicular liposome technology. Clin Pharmacokinet. 2006;45:1153–76. - PubMed
    1. Bangham AD, Standish MM, Watkins JC. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol. 1965;13:238–52. - PubMed
    1. Benesch M, Sovinz P, Krammer B, et al. Feasibility and toxicity of intrathecal liposomal cytarabine in 5 children and young adults with refractory neoplastic meningitis. J Pediatr Hematol Oncol. 2007;29:222–6. - PubMed