Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Apr;41(4):385-6.
doi: 10.1038/ng0409-385.

Somatic and germline genetics at the JAK2 locus

Peter J Campbell  1
Affiliations
Comment

Somatic and germline genetics at the JAK2 locus

Peter J Campbell. Nat Genet. 2009 Apr.

Abstract

Myeloproliferative neoplasms are hematological malignancies frequently associated with somatically acquired mutation of the JAK2 gene. A new study shows that these mutations are preferentially found within a particular inherited JAK2 haplotype, implying the existence of a strong, but uncharacterized, interaction between somatic and germline genetics at this locus.

PubMed Disclaimer

Comment on

References

    1. PLoS Med. 2006 Jul;3(7):e270 - PubMed
    1. Blood. 2008 Sep 15;112(6):2199-204 - PubMed
    1. Blood. 2005 Oct 15;106(8):2688-92 - PubMed
    1. N Engl J Med. 2006 Dec 7;355(23):2452-66 - PubMed
    1. Blood. 2007 Jan 1;109(1):339-42 - PubMed

LinkOut - more resources