BMP6 orchestrates iron metabolism
- PMID: 19338078
- DOI: 10.1038/ng0409-386
BMP6 orchestrates iron metabolism
Abstract
The small liver peptide hepcidin is a major regulator of systemic iron homeostasis in mammals, adapting iron absorption to the body's demands. Two new studies now identify BMP6 as the key endogenous regulator of hepcidin.
Comment on
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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.Nat Genet. 2009 Apr;41(4):482-7. doi: 10.1038/ng.335. Epub 2009 Mar 1. Nat Genet. 2009. PMID: 19252486 Free PMC article.
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Lack of the bone morphogenetic protein BMP6 induces massive iron overload.Nat Genet. 2009 Apr;41(4):478-81. doi: 10.1038/ng.320. Epub 2009 Mar 1. Nat Genet. 2009. PMID: 19252488
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