Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jan;4(1):52-6.
doi: 10.1097/COH.0b013e32831a7246.

Human papillomavirus-related disease in people with HIV

Joel Palefsky  1
Affiliations
Review

Human papillomavirus-related disease in people with HIV

Joel Palefsky. Curr Opin HIV AIDS. 2009 Jan.

Abstract

Purpose of review: The incidence of human papillomavirus (HPV)-related cancers has increased among people with HIV infection compared with the general population. This review will describe recent findings in HPV-associated cancer incidence since the introduction of antiretroviral therapy, HPV/disease prevalence at sites other than cervix and anus, and recent data on screening and treatment of anal intraepithelial neoplasia.

Recent findings: Consistent with high prevalence of anogenital HPV infection, new data on cervical intraepithelial neoplasia and anal intraepithelial neoplasia in HIV-positive men and women show that the incidence of cervical cancer has not declined since the introduction of antiretroviral therapy and that the incidence of anal cancer is rising. Several studies also highlight high rates of HPV infection and HPV-associated disease at sites other than the cervix and anus, including the penis and the mouth. Treatment methods for anal intraepithelial neoplasia have been described and show reasonable efficacy.

Summary: New data imply that the problem of HPV-related cancers will not decline among HIV-positive men and women in the antiretroviral therapy era, highlighting the need to perform studies to determine if screening and treatment of anal intraepithelial neoplasia will prevent development of anal cancer. Recent data show progress in both these areas.

PubMed Disclaimer

References

    1. Frisch M, Biggar RJ, Engels EA, Goedert JJ. Association of cancer with AIDS-related immunosuppression in adults. Jama. 2001 Apr 4;285(13):1736–45. - PubMed
    1. Frisch M, Goodman MT. Human papillomavirus-associated carcinomas in Hawaii and the mainland U.S. Cancer. 2000 Mar 15;88(6):1464–9. - PubMed
    1. Palefsky JM, Holly EA, Ralston ML, Da Costa M, Bonner H, Jay N, et al. Effect of highly active antiretroviral therapy on the natural history of anal squamous intraepithelial lesions and anal human papillomavirus infection. J Acquir Immune Defic Syndr. 2001 Dec 15;28(5):422–8. - PubMed
    1. Hessol NA, Pipkin S, Schwarcz S, Cress RD, Bacchetti P, Scheer S. The impact of highly active antiretroviral therapy on non-AIDS-defining cancers among adults with AIDS. Am J Epidemiol. 2007 May 15;165(10):1143–53. - PubMed

    2. Using an AIDS-Cancer registry match, this paper showed that the relative hazard of developing anal cancer among HIV-positive individuals in San Francisco was 2.9 in the post-ART era compared with the pre-ART era.

    1. Bower M, Palmieri C, Dhillon T. AIDS-related malignancies: changing epidemiology and the impact of highly active antiretroviral therapy. Curr Opin Infect Dis. 2006 Feb;19(1):14–9. - PubMed

MeSH terms

Substances