From telogen to exogen: mechanisms underlying formation and subsequent loss of the hair club fiber

Abstract

The hair follicle has the unique capacity to undergo periods of growth, regression, and rest before regenerating itself to restart the cycle. This dynamic cycling capacity enables mammals to change their coats, and for hair length to be controlled on different body sites. More recently, the process of club fiber shedding has been described as a distinct cycle phase known as exogen, and proposed to be an active phase of the hair cycle. This review focuses on the importance of the shedding phase of the hair cycle and, in the context of current literature, analyzes the processes of club fiber formation, retention, and release, which may influence progression through exogen, particularly in relation to human hair.