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Review
. 2009 Feb;21(1):105-10.
doi: 10.1016/j.coi.2009.03.011. Epub 2009 Apr 1.

Antigen presentation by dendritic cells in vivo

Elodie Segura  1 , José A Villadangos
Affiliations
Review

Antigen presentation by dendritic cells in vivo

Elodie Segura et al. Curr Opin Immunol. 2009 Feb.

Abstract

Dendritic cells (DC) are heterogenous, comprising several subpopulations of migratory and lymphoid-organ-resident types. Recent studies addressing the role of each subset in antigen presentation in vivo have revealed a complex division of labor within the DC network. In addition to CD8(+) DC, migratory lung or dermal DC can cross-present antigen in vivo. Migratory DC also transport to the lymph nodes antigens that can be transferred to resident DC for presentation. In inflammatory conditions, the antigen-presentation abilities of DC can be severely impaired, but an additional population of monocyte-derived DC then comes into play. Understanding the contribution of each DC subset to a physiological immune response is particularly relevant for rational vaccine design.

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Comment in

  • Editorial overview.
    Ploegh H, Amigorena S. Ploegh H, et al. Curr Opin Immunol. 2009 Feb;21(1):68-9. doi: 10.1016/j.coi.2009.03.005. Epub 2009 Apr 1. Curr Opin Immunol. 2009. PMID: 19342209 No abstract available.

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