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Review
. 2009 May;9(5):361-71.
doi: 10.1038/nrc2628. Epub 2009 Apr 3.

Tumour necrosis factor and cancer

Frances Balkwill  1
Affiliations
Review

Tumour necrosis factor and cancer

Frances Balkwill. Nat Rev Cancer. 2009 May.

Abstract

Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to harness this anti-tumour activity in cancer treatments were underway, a paradoxical tumour-promoting role of TNF became apparent. Now that links between inflammation and cancer are appreciated, is TNF a target or a therapeutic in malignant disease -- or both?

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