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. 2008;5(1):25-36.
doi: 10.1016/j.ddstr.2008.05.006.

Cyclooxygenase products and atherosclerosis

Macrae F Linton  1 , Sergio Fazio
Affiliations

Cyclooxygenase products and atherosclerosis

Macrae F Linton et al. Drug Discov Today Ther Strateg. 2008.
No abstract available

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Figures

Figure 1
Figure 1
Arachidonic acid (AA) is first oxidized by cyclooxygenase (COX)-1 or COX-2 to PGG2, which is then peroxidized to PGH2, an unstable endoperoxide that serves as the common precursor for the 5 principle prostaglandins. Synthesis of Thromboxane(TX) A2, PGI2, PGE2, PGD2, and PGF2a is mediated by specific synthases (TXAS, PGIS, PGES, PGDS, and PGFS). * Three synthases have been identified for PGE2: cPGES, mPGES-1, and mPGES-2; two synthases generate PGD2. Prostaglandins mediate their biological effects by activating the indicated cell surface G-protein-coupled receptors[111].
Figure 2
Figure 2
Proposed roles for prostaglandins in atherothrombosis according to cell type.
See this image and copyright information in PMC

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