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Comparative Study
. 2009 May;145(4):529-32.
doi: 10.1111/j.1365-2141.2009.07660.x. Epub 2009 Mar 27.

Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness

Julie Makani  1 , Fenella J Kirkham, Albert Komba, Tolulope Ajala-Agbo, Godfrey Otieno, Gregory Fegan, Thomas N Williams, Kevin Marsh, Charles R Newton
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Free PMC article
Comparative Study

Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness

Julie Makani et al. Br J Haematol. 2009 May.
Free PMC article

Abstract

High cerebral blood flow velocity (CBFv) and low haemoglobin oxygen saturation (SpO(2)) predict neurological complications in sickle cell anaemia (SCA) but any association is unclear. In a cross-sectional study of 105 Kenyan children, mean CBFv was 120 +/- 34.9 cm/s; 3 had conditional CBFv (170-199 cm/s) but none had abnormal CBFv (>200 cm/s). After adjustment for age and haematocrit, CBFv > or =150 cm/s was predicted by SpO(2) < or = 95% and history of fever. Four years later, 10 children were lost to follow-up, none had suffered neurological events and 11/95 (12%) had died, predicted by history of fever but not low SpO(2). Natural history of SCA in Africa may be different from North America and Europe.

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