beta-tting on p63 as a metastatic suppressor
- PMID: 19345184
- DOI: 10.1016/j.cell.2009.03.028
beta-tting on p63 as a metastatic suppressor
Abstract
Although much is known about the genes that promote metastasis, few suppressors of metastasis have been found. Adorno et al. (2009) now identify p63 as a potent suppressor of metastasis and uncover an intricate mechanism for the inactivation of metastasis in cancer cells in response to transforming growth factor beta.
Comment on
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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis.Cell. 2009 Apr 3;137(1):87-98. doi: 10.1016/j.cell.2009.01.039. Cell. 2009. PMID: 19345189
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