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. 2009 Apr;80(4):536-40.

The Santa Lucia strain of Plasmodium falciparum in Aotus monkeys

William E Collins  1 , Joann S Sullivan, Allison Williams, G Gale Galland, Douglas Nace, Tyrone Williams, John W Barnwell
Affiliations
  • PMID: 19346371

The Santa Lucia strain of Plasmodium falciparum in Aotus monkeys

William E Collins et al. Am J Trop Med Hyg. 2009 Apr.

Abstract

The Santa Lucia strain of Plasmodium falciparum was studied in 150 Aotus lemurinus griseimembra, 30 A. azarae boliviensis, 103 A. nancymaae, and 121 A. vociferans monkeys. All four of these splenectomized hosts supported the production of gametocytes infective to Anopheles freeborni mosquitoes. Transmission through sporozoites from An. freeborni, An. stephensi, An. maculatus, and An. albimanus mosquitoes was successful to all four species of Aotus on a total of 100 occasions with a median pre-patent period of 21 days. For the production of infective mosquitoes for vaccine challenge studies, A. l. griseimembra and A. vociferans were the most predictable hosts.

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