Assessing the outcomes of prolonged cessation-induction and aid-to-cessation trials: floating prolonged abstinence
- PMID: 19346506
- PMCID: PMC2671463
- DOI: 10.1093/ntr/ntp035
Assessing the outcomes of prolonged cessation-induction and aid-to-cessation trials: floating prolonged abstinence
Abstract
Introduction: A Society for Research on Nicotine and Tobacco working group recommended outcome measures for cessation-induction trials and aid-to-cessation trials. Cessation-induction trials aim to motivate unwilling quitters to make a quit attempt. Aid-to-cessation trials give either medication or behavioral interventions to increase the rate at which willing quitters succeed in their attempts. Nicotine-assisted reduction programs combine features of both types of interventions by giving nicotine replacement to unwilling quitters. Treatment can be prolonged more than a year, quit attempts can occur and succeed early or late in the program, and renewed quit attempts are an inherent part of the program. Conventional outcome measures are tied to a fixed but arbitrary point in follow-up and cannot capture the true outcome: Prolonged cessation anchored to the point at which a person makes a successful quit attempt.
Discussion: We propose that the outcome should be counted from the successful quit attempt that began during the treatment period and continues for a defined period, ideally 6 months. In particular, if a trial compared a short reduction program with a long reduction program, it would not be possible to obtain an unbiased assessment of the outcome of such a trial using a measure tied to a fixed point in follow-up. Floating prolonged abstinence could provide such an assessment and is suitable for either prolonged cessation-induction trial or combined cessation-induction and aid-to-cessation trials.
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References
-
- Aveyard P, Griffin C, Lawrence PT, Cheng KK. A controlled trial of an expert system and self-help manual intervention based on the stages of change versus standard self-help materials in smoking cessation. Addiction. 2003;98:345–354. - PubMed
-
- Batra A, Klingler K, Landfeldt B, Friederich HM, Westin A, Danielsson T. Smoking reduction treatment with 4-mg nicotine gum: A double-blind, randomized, placebo-controlled study. Clinical Pharmacology & Therapeutics. 2005;78:689–696. - PubMed
-
- Cahill K, Stead LF, Lancaster T. Nicotine receptor partial agonists for smoking cessation. Cochrane Database of Systematic Reviews. 2007 3, Art. No.: CD006103; doi: 10.1002/14651858.CD006103.pub3. - PubMed
-
- Etter J.-F., Laszlo E, Zellweger J.-P., Perrot C, Perneger TV. Nicotine replacement to reduce cigarette consumption in smokers who are unwilling to quit: A randomized trial. Journal of Clinical Psychopharmacology. 2002;22:487–495. - PubMed
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