Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 May;41(5):591-5.
doi: 10.1038/ng.348. Epub 2009 Apr 6.

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

Yoichiro Kamatani  1 , Sukanya Wattanapokayakit, Hidenori Ochi, Takahisa Kawaguchi, Atsushi Takahashi, Naoya Hosono, Michiaki Kubo, Tatsuhiko Tsunoda, Naoyuki Kamatani, Hiromitsu Kumada, Aekkachai Puseenam, Thanyachai Sura, Yataro Daigo, Kazuaki Chayama, Wasun Chantratita, Yusuke Nakamura, Koichi Matsuda
Affiliations

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

Yoichiro Kamatani et al. Nat Genet. 2009 May.

Abstract

Chronic hepatitis B is a serious infectious liver disease that often progresses to liver cirrhosis and hepatocellular carcinoma; however, clinical outcomes after viral exposure vary enormously among individuals. Through a two-stage genome-wide association study using 786 Japanese chronic hepatitis B cases and 2,201 controls, we identified a significant association of chronic hepatitis B with 11 SNPs in a region including HLA-DPA1 and HLA-DPB1. We validated these associations by genotyping two SNPs from the region in three additional Japanese and Thai cohorts consisting of 1,300 cases and 2,100 controls (combined P = 6.34 x 10(-39) and 2.31 x 10(-38), OR = 0.57 and 0.56, respectively). Subsequent analyses revealed risk haplotypes (HLA-DPA1(*)0202-DPB1(*)0501 and HLA-DPA1(*)0202-DPB1(*)0301, OR = 1.45 and 2.31, respectively) and protective haplotypes (HLA-DPA1(*)0103-DPB1(*)0402 and HLA-DPA1(*)0103-DPB1(*)0401, OR = 0.52 and 0.57, respectively). Our findings show that genetic variants in the HLA-DP locus are strongly associated with risk of persistent infection with hepatitis B virus.

PubMed Disclaimer

Comment in

References

    1. Am J Hum Genet. 2002 Feb;70(2):425-34 - PubMed
    1. Int Immunol. 1996 Apr;8(4):525-31 - PubMed
    1. J Hum Genet. 2002;47(7):360-5 - PubMed
    1. Hepatology. 2000 Jun;31(6):1371-3 - PubMed
    1. J Hepatol. 1997 Mar;26(3):503-7 - PubMed

Publication types

LinkOut - more resources