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. 2009 May;41(5):596-601.
doi: 10.1038/ng.347. Epub 2009 Apr 6.

A common variant on chromosome 11q13 is associated with atopic dermatitis

Jorge Esparza-Gordillo  1 , Stephan Weidinger, Regina Fölster-Holst, Anja Bauerfeind, Franz Ruschendorf, Giannino Patone, Klaus Rohde, Ingo Marenholz, Florian Schulz, Tamara Kerscher, Norbert Hubner, Ulrich Wahn, Stefan Schreiber, Andre Franke, Rainer Vogler, Simon Heath, Hansjörg Baurecht, Natalija Novak, Elke Rodriguez, Thomas Illig, Min-Ae Lee-Kirsch, Andrzej Ciechanowicz, Michael Kurek, Tereza Piskackova, Milan Macek, Young-Ae Lee, Andreas Ruether
Affiliations

A common variant on chromosome 11q13 is associated with atopic dermatitis

Jorge Esparza-Gordillo et al. Nat Genet. 2009 May.

Abstract

We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P(combined) = 7.6 x 10(-10)). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.

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References

    1. Clin Allergy. 1979 May;9(3):221-3 - PubMed
    1. Nature. 1999 Nov 25;402(6760 Suppl):B5-11 - PubMed
    1. Nat Rev Genet. 2005 May;6(5):376-88 - PubMed
    1. J Am Acad Dermatol. 1993 May;28(5 Pt 1):719-23 - PubMed
    1. J Allergy Clin Immunol. 2008 May;121(5):1203-1209.e1 - PubMed

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