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Comment
. 2009 Apr;15(4):367-9.
doi: 10.1038/nm0409-367.

Neuropeptide beckons cells that heal

Pamela Gehron Robey
Comment

Neuropeptide beckons cells that heal

Pamela Gehron Robey. Nat Med. 2009 Apr.

Abstract

Experiments in rodents identify a factor that causes the release of multipotent cells into the circulation after injury. These cells contribute to tissue repair.

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Figures

Figure 1
Figure 1
Substance P helps in healing. In experiments performed by Hong et al., corneal injury releases the neuropeptide substance P (SP) into the circulation. This release, or direct injection of substance P, elicits the appearance of CD29+ (β1 integrin subunit) cells into the circulation. These blood-borne cells become adherent in plastic culture dishes and are able to form cartilage in vitro and bone in vivo. These cells also participate in healing of the cornea.
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