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. 2009 Apr 29;131(16):5728-9.
doi: 10.1021/ja900591t.

Photoregulated release of caged anticancer drugs from gold nanoparticles

Sarit S Agasti  1 , Apiwat Chompoosor, Chang-Cheng You, Partha Ghosh, Chae Kyu Kim, Vincent M Rotello
Affiliations

Photoregulated release of caged anticancer drugs from gold nanoparticles

Sarit S Agasti et al. J Am Chem Soc. .

Abstract

An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.

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Figures

Figure 1
Figure 1
a) Photochemical reaction of Au_PCFU and delivery of payload to cell. b) Overlaid UV-Vis spectral changes showing light dose dependent increase of 5-FU concentration. Inset: The plot of absorbance at 265 nm against irradiation time.
Figure 2
Figure 2
The bright-field and fluorescence-microscopy images of the cells irradiating before treated with Au_PCFU (a and c) and irradiating after treated with Au_PCFU (b and d) with light.
Figure 3
Figure 3
a) The cytotoxicity of different concentration of Au_PCFU under caging and control condition. The IC50 value was 0.7 μM per particle, 11.9 μM per drug. b) The effect of different condition on the cell viability of MCF-7 cell line. The concentration of Au_PCFU used is 1 μM and the light exposure time is 20 min. c) Cell viability with different durations of light exposure.
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