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. 2009 Apr 15;131(14):5070-1.
doi: 10.1021/ja901153s.

Hydrocarbamoylation of unsaturated bonds by nickel/Lewis-acid catalysis

Yoshiaki Nakao  1 , Hiroaki Idei, Kyalo Stephen Kanyiva, Tamejiro Hiyama
Affiliations

Hydrocarbamoylation of unsaturated bonds by nickel/Lewis-acid catalysis

Yoshiaki Nakao et al. J Am Chem Soc. .

Abstract

Formamides are found to undergo addition reactions across alkynes and 1,3-dienes by nickel/Lewis acid catalysis to give a variety of alpha,beta- and beta,gamma-unsaturated amides with stereo- and regioselectivity. Intramolecular insertion reactions of olefins into the C-H bonds of formamides also proceed under similar conditions. The presence of Lewis acid cocatalysts is crucial, and formamide coordination to the Lewis acid is considered to be responsible for the activation of their formyl C-H bonds probably through oxidative addition to nickel(0).

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