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Editorial
. 2009;11(2):106.
doi: 10.1186/ar2646. Epub 2009 Mar 26.

The changing landscape of the clinical value of the PM/Scl autoantibody system

Michael Mahler, Marvin J Fritzler
Editorial

The changing landscape of the clinical value of the PM/Scl autoantibody system

Michael Mahler et al. Arthritis Res Ther. 2009.

Abstract

Autoantibodies to the polymyositis/scleroderma (PM/Scl) complex have been associated with systemic sclerosis and PM/Scl overlap syndrome. The report of Hanke and colleagues in a recent issue of Arthritis Research and Therapy is the first to describe the separate evaluation of anti-PM/Scl-75c and PM/Scl-100 autoantibodies and their relationship to clinical manifestations of systemic sclerosis. Several observations are of paramount interest, but are not in general agreement with earlier studies. These include the prevalence of anti-PM/Scl antibodies in systemic sclerosis, the association with certain clinical manifestations and prognosis of patients. This report will hopefully trigger systematic multi-centre studies to confirm and/or elucidate the novel line immunoassay and clinical associations.

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References

    1. Hanke K, Brückner CS, Dähnrich C, Huscher D, Komorowski L, Meyer W, Janssen A, Backhaus M, Becker M, Kill A, Egerer K, Burmester GR, Hiepe F, Schlumberger W, Riemekasten G. Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients. Arthritis Res Ther. 2009;11:R22. doi: 10.1186/ar2614. - DOI - PMC - PubMed
    1. Mahler M, Raijmakers R. Novel aspects of autoantibodies to the PM/Scl complex: clinical, genetic and diagnostic insights. Autoimmun Rev. 2007;6:432–437. doi: 10.1016/j.autrev.2007.01.013. - DOI - PubMed
    1. Mahler M, Raijmakers R, Dähnrich C, Blüthner M, Fritzler MJ. Clinical evaluation of autoantibodies to a novel PM/Scl peptide antigen. Arthritis Res Ther. 2005;7:R704–R713. doi: 10.1186/ar1729. - DOI - PMC - PubMed
    1. Mahler M, Fritzler MJ. PM1-Alpha ELISA: The assay of choice for the detection of anti-PM/Scl autoantibodies? Autoimmun Rev. 2008;8:373–378. doi: 10.1016/j.autrev.2008.12.001. - DOI - PubMed
    1. Fritzler MJ. Advances and applications of multiplexed diagnostic technologies in autoimmune diseases. Lupus. 2006;15:422–427. doi: 10.1191/0961203306lu2327oa. - DOI - PubMed

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