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Comment
. 2009 Apr 15;15(8):2581-2.
doi: 10.1158/1078-0432.CCR-09-0003. Epub 2009 Apr 7.

Lung cancer genetics: a family affair?

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Comment

Lung cancer genetics: a family affair?

David C Christiani. Clin Cancer Res. .

Abstract

Lung cancer risk has a genetic component. This study reports the discovery of a gene variant that is overexpressed in patients who have the familial, but not sporadic, type of lung cancer. This report provides new insights into a mechanism that will help to guide preventive interventions in the future.

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  • Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.
    You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW. You M, et al. Clin Cancer Res. 2009 Apr 15;15(8):2666-74. doi: 10.1158/1078-0432.CCR-08-2335. Epub 2009 Apr 7. Clin Cancer Res. 2009. PMID: 19351763 Free PMC article.

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