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. 2009 Apr;27(4):320-1.
doi: 10.1038/nbt0409-320.

A kernel for the Tropical Disease Initiative

Leticia Ortí  1 , Rodrigo J Carbajo, Ursula Pieper, Narayanan Eswar, Stephen M Maurer, Arti K Rai, Ginger Taylor, Matthew H Todd, Antonio Pineda-Lucena, Andrej Sali, Marc A Marti-Renom
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A kernel for the Tropical Disease Initiative

Leticia Ortí et al. Nat Biotechnol. 2009 Apr.
No abstract available

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Figures

Figure 1
Figure 1
TDI kernel snapshot of the web page for the Plasmodium falciparum thymidylate kinase target (http://tropicaldisease.org/kernel/q8i4s1/). Our computational pipeline predicted that thymidylate kinase from P. falciparum binds ATM (3'-azido-3'-deoxythymidine-5'-monophosphate), a supra-structure of the Zidovudine drug approved for the treatment of HIV infection. The binding of this ligand to a site on the kinase was experimentally validated by 1D Water-LOGSY and Saturation Transfer Difference NMR experiments.
See this image and copyright information in PMC

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