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Review
. 2009 May 5;100(9):1369-72.
doi: 10.1038/sj.bjc.6605007. Epub 2009 Apr 7.

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

T Mashima  1 , H Seimiya, T Tsuruo
Affiliations
Review

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

T Mashima et al. Br J Cancer. .

Abstract

Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes in de novo fatty-acid synthesis and related pathways.

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Figures

Figure 1
Figure 1
Coupling of elevated fatty-acid metabolism with growth factor signalling in cancer. Growth factors and hormone receptors play essential roles in tumour-related FASN overexpression. FASN and growth factor-dependent signalling are mutually regulated in cancer cells. Tumour microenvironment stress, as well as multiple other factors are involved in FASN overexpression and elevated lipogenesis in cancer. ACLY, ATP citrate lyase; ACC, acetyl-CoA carboxylase; FASN, fatty-acid synthase; ACS, acyl-CoA synthetase; EGFR, epidermal growth factor receptor; ER, oestrogen receptor; AR, androgen receptor; PR, progesterone receptor; PI3K, phosphatidylinositol-3-kinase; MAPK, mitogen-activated protein kinase; SREBP-1c, sterol regulatory element-binding protein 1c; USP2a, ubiquitin-specific protease-2a.
See this image and copyright information in PMC

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