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. 2009 May 5;100(9):1434-7.
doi: 10.1038/sj.bjc.6605028. Epub 2009 Apr 7.

Lack of complex I is associated with oncocytic thyroid tumours

F A Zimmermann  1 , J A Mayr, D Neureiter, R Feichtinger, B Alinger, N D Jones, W Eder, W Sperl, B Kofler
Affiliations

Lack of complex I is associated with oncocytic thyroid tumours

F A Zimmermann et al. Br J Cancer. .

Abstract

Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue.

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Figures

Figure 1
Figure 1
Representative immunohistochemical staining of all respiratory chain enzyme complexes and porin of an oncocytic thyroid adenoma. (A) Positive staining for complex I subunit NDUFS4 in normal thyroid tissue (upper part) and immunonegative staining in oncocytic tumour tissue (lower part). (B–E) Increased expression of respiratory chain complex II subunit 70 kDa (B), complex III subunit core 2 (C), complex IV subunit I (D) and complex V subunit-α (E) in oncocytic tumour compared with adjacent normal tissue. (F) Immunohistochemical staining of porin reveals the characteristic upregulation of mitochondria in oncocytic tumour cells compared with normal thyroid tissue.
Figure 2
Figure 2
Score values for staining intensity of immunopositive cells in normal and tumour tissues of 19 patients with oncocytic thyroid tumours with complex I and complex V antibodies, respectively.
See this image and copyright information in PMC

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