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. 1991 Sep;48(3):205-7.

Tegafur-induced acral hyperpigmentation

E Llistosella  1 , A Codina, R Alvarez, R M Pujol, J M de Moragas
Affiliations
  • PMID: 1935249

Tegafur-induced acral hyperpigmentation

E Llistosella et al. Cutis. 1991 Sep.

Abstract

Four patients with colorectal cancer treated with tegafur (a fluoropyrimidine structurally similar to 5-fluorouracil) noted a macular, spotted hyperpigmentation limited to the palms, soles, nails, and glans penis. Histopathologic examination disclosed epidermal basal hyperpigmentation with a lentiginous pattern. Mucocutaneous lesions resolved spontaneously two months after treatment was discontinued. This peculiar phenomenon seems to represent a previously unreported side effect of this cytotoxic drug.

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