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. 2009 Jun;89(5):584-91.
doi: 10.1007/s12185-009-0285-6. Epub 2009 Apr 8.

Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study

Ekaterini Kidas  1 , Anja Möricke, Rita Beier, Karl Welte, Martin Schrappe, Martin Stanulla, Lorenz Grigull
Affiliations

Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study

Ekaterini Kidas et al. Int J Hematol. 2009 Jun.

Abstract

Specific mutations of the TNF-alpha (TNF-alpha) and Lymphotoxin-alpha (LT-alpha) genes are correlated to the outcome of patients during serious infections. This study aimed at correlating these polymorphisms to lethal infections during childhood acute lymphoblastic leukemia (ALL). A matched case-control study of 34 patients who died due to infections during ALL treatment and 68 ALL patients without lethal infections was performed. Genomic DNA was isolated from blood smears and specific fragments including the polymorphic site of each gene were amplified. In the total study population, 23/102 (22.5%) of the children carried at least two variant alleles (high-producer haplotype). The variant genotypes were equally distributed between cases and controls [relative risk (RR) 1.17 (CI 0.33-2.22, P = 0.752)]. With regard to infective organisms, no statistically significant differences could be detected between the groups for bacterial infections [RR 1.59 (CI 0.56-4.50), P 0.379]. Patients with a LT-alpha (10.5 kb/5.5 kb; 5.5 kb/5.5 kb) haplotype, however, seemed to have a significant higher risk of attracting a lethal infection during induction/consolidation chemotherapy (RR 2.98, CI 0.98-9.01, P = 0.05). These results support a role of specific genetic polymorphisms on lethal infections during induction chemotherapy of ALL treatment.

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References

    1. Hann I, Viscoli C, Paesmans M, Gaya H, Glauser M. A comparison of outcome from febrile neutropenic episodes in children compared with adults: results from four EORTC studies. International Antimicrobial Therapy Cooperative Group (IATCG) of the European Organization for Research and Treatment of Cancer (EORTC) Br J Haematol. 1997;99:580–588. doi: 10.1046/j.1365-2141.1997.4453255.x. - DOI - PubMed
    1. Grigull L, Beier R, Schrauder A, Kirschner P, Loening L, Jack T, et al. Invasive fungal infections are responsible for one-fifth of the infectious deaths in children with ALL. Mycoses. 2003;46:441–446. doi: 10.1046/j.0933-7407.2003.00931.x. - DOI - PubMed
    1. Rossi C, Klastersky J. Initial empirical antibiotic therapy for neutropenic fever: analysis of the causes of death. Support Care Cancer. 1996;4:207–212. doi: 10.1007/BF01682342. - DOI - PubMed
    1. Ashkenazi S, Leibovici L, Samra Z, Konisberger H, Drucker M. Risk factors for mortality due to bacteremia and fungemia in childhood. Clin Infect Dis. 1992;14:949–951. - PubMed
    1. Lehrnbecher T, Chanock SJ. Controversies in the treatment of neutropenia in cancer patients. Curr Opin Hematol. 1998;5:26–32. doi: 10.1097/00062752-199801000-00005. - DOI - PubMed

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