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Review
. 2009 Apr;9(3):242-54.
doi: 10.2174/156652409787847263.

Cytokines in systemic lupus erythematosus

Elaine V Lourenço  1 , Antonio La Cava
Affiliations
Review

Cytokines in systemic lupus erythematosus

Elaine V Lourenço et al. Curr Mol Med. 2009 Apr.

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that can form immune complexes and deposit in tissues, causing inflammation and organ damage. There is evidence that interferons and some interleukins can have an active role in the pathogenesis of SLE and can contribute significantly to the immune imbalance in the disease, whereas the role of some cytokines (such as TNF) is still debated. This review discusses the activity of several cytokines in SLE, their effects on the immune cells in relation to the disease pathogenesis, and the promise and limitations of cytokine-based therapies in clinical trials for lupus patients.

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Figures

Fig. (1)
Fig. (1)
Schematic representation of the positive (+) and negative (−) effects that cytokines have on development and function of T cells.
See this image and copyright information in PMC

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