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. 2008 Dec;2(4):286-9.
doi: 10.2174/187231208786734157.

Covariates of amikacin clearance in neonates: the impact of postnatal age on predictability

Karel Allegaert  1 , Isabelle Scheers, Veerle Cossey, Brian J Anderson
Affiliations

Covariates of amikacin clearance in neonates: the impact of postnatal age on predictability

Karel Allegaert et al. Drug Metab Lett. 2008 Dec.

Abstract

An earlier reported population pharmacokinetic study documented limited predictability of amikacin clearance (65%) at birth. An exercise in the first month of life resulted in extended predictability (92%) with similar clearance estimates after the first postnatal days, reflecting the impact of postnatal age on clearance predictability.

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