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Comment
. 2009 Apr;9(4):303-5.
doi: 10.1016/j.cmet.2009.03.008.

The insulin receptor talks to glucagon?

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The insulin receptor talks to glucagon?

Jesper Gromada et al. Cell Metab. 2009 Apr.
Free article

Abstract

Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.

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