The insulin receptor talks to glucagon?
- PMID: 19356709
- DOI: 10.1016/j.cmet.2009.03.008
The insulin receptor talks to glucagon?
Abstract
Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.
Comment on
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Insulin signaling in alpha cells modulates glucagon secretion in vivo.Cell Metab. 2009 Apr;9(4):350-61. doi: 10.1016/j.cmet.2009.02.007. Cell Metab. 2009. PMID: 19356716 Free PMC article.
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