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Multicenter Study
. 2009 Jun;47(6):1902-5.
doi: 10.1128/JCM.02304-08. Epub 2009 Apr 8.

Correlation of cefoxitin MICs with the presence of mecA in Staphylococcus spp

Jana M Swenson  1 , William B Brasso, Mary Jane Ferraro, Dwight J Hardy, Cynthia C Knapp, David Lonsway, Sigrid McAllister, L Barth Reller, Helio S Sader, Dee Shortridge, Robert Skov, Melvin P Weinstein, Barbara L Zimmer, Jean B Patel
Affiliations
Multicenter Study

Correlation of cefoxitin MICs with the presence of mecA in Staphylococcus spp

Jana M Swenson et al. J Clin Microbiol. 2009 Jun.

Abstract

This report describes the results of an 11-laboratory study to determine if a cefoxitin broth microdilution MIC test could predict the presence of mecA in staphylococci. Using breakpoints of < or = 4 microg/ml for mecA-negative and > or = 6 or 8 microg/ml for mecA-positive isolates, sensitivity and specificity based on mecA or presumed mecA for Staphylococcus aureus at 18 h of incubation were 99.7 to 100% in three cation-adjusted Mueller-Hinton broths tested. For coagulase-negative strains at 24 h of incubation, breakpoints of < or = 2 microg/ml for mecA-negative and > or = 4 microg/ml for mecA-positive isolates gave sensitivity and specificity of 94 to 99% and 69 to 80%, respectively.

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