Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Apr 14;106(15):6027-8.
doi: 10.1073/pnas.0902226106. Epub 2009 Apr 8.

Shifting replication between IInd, IIIrd, and IVth gears

Justin Courcelle  1
Affiliations
Comment

Shifting replication between IInd, IIIrd, and IVth gears

Justin Courcelle. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Models for translesion DNA polymerase function during replication in the presence of DNA damage. (A) Translesional polymerases (green circles) replace Pol III (red circles) at replication forks (i), slowing the speed of replication and allowing more time for the damage (blue Xs) to be repaired (ii). (B) After replication encounters unrepaired damage (i), the translesion DNA polymerases function to fill in the gaps left in the DNA at these sites (ii).
See this image and copyright information in PMC

Comment on

References

    1. Nelson JR, Lawrence CW, Hinkle DC. Deoxycytidyl transferase activity of yeast REV1 protein. Nature. 1996;382:729–731. - PubMed
    1. Nelson JR, Lawrence CW, Hinkle DC. Thymine–thymine dimer bypass by yeast DNA polymerase zeta. Science. 1996;272:1646–1649. - PubMed
    1. Wagner J, Etienne H, Janel-Bintz R, Fuchs RP. Genetics of mutagenesis in E. coli: Various combinations of translesion polymerases (Pol II, IV, and V) deal with lesion/sequence context diversity. DNA Repair. 2002;1:159–167. - PubMed
    1. Indiani C, Langston LD, Yurieva O, Goodman MF, O'Donnell M. Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase. Proc Natl Acad Sci USA. 2009;106:6031–6038. - PMC - PubMed
    1. Uchida K, et al. Overproduction of Escherichia coli DNA polymerase DinB (Pol IV) inhibits replication fork progression and is lethal. Mol Microbiol. 2008;70:608–622. - PubMed

Publication types

MeSH terms

LinkOut - more resources