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Comparative Study
. 2009 Apr;40(2):235-9.
doi: 10.1016/j.ocl.2009.01.004.

Does statin usage reduce the risk of corticosteroid-related osteonecrosis in renal transplant population?

Muhammad Ajmal  1 , A J Matas, Michael Kuskowski, Edward Y Cheng
Affiliations
Comparative Study

Does statin usage reduce the risk of corticosteroid-related osteonecrosis in renal transplant population?

Muhammad Ajmal et al. Orthop Clin North Am. 2009 Apr.

Abstract

The relationship between corticosteroids and osteonecrosis is well known. Limited data suggest that statins modulate cholesterol metabolism and may protect against osteonecrosis. The authors analyzed their prospective renal transplant database to determine if statin usage reduces the incidence of corticosteroid-related osteonecrosis and identified 2,881 renal transplantation patients who met the entry criteria. Among 338 patients on statins, 15 (4.4%) developed osteonecrosis, versus 180 of 2,543 (7%) patients who were not on statins. Osteonecrosis-free survival was similar in patients with and without statin exposure.

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Figures

Fig 1
Fig 1
A univariate Kaplan-Meier life table analysis of ON-free survival of kidney transplant patients on statins identified no trend in ON risk reduction for patients taking statins (p = 0.14, log-rank). Error bars = 95% confidence intervals.
See this image and copyright information in PMC

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