Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Apr-Jun;16(2):103-6.
doi: 10.1007/BF03189945.

Induction of cytochrome P-450 isozymes upon repeated administration of nifedipine

M Koleva  1 , T Stoytchev, L Gulyaeva, A Grishanova, V Mishin, V Lyakhovich
Affiliations

Induction of cytochrome P-450 isozymes upon repeated administration of nifedipine

M Koleva et al. Eur J Drug Metab Pharmacokinet. 1991 Apr-Jun.

Abstract

In experiments on male Wistar rats it has been found that nifedipine administration at a dose of 10 mg/kg body weight i.p. daily for 20 days did not significantly increase the total amount of cytochrome P-450 but markedly increased the 7 alpha-, 16 beta- and 6 beta-hydroxylation of androstenedione in liver microsomes, suggesting the induction of cytochromes P-450IIA1, P-450IIB1, and P-450IIIA1, respectively. The induction of cytochrome P-450IIIB1 was also confirmed immunochemically with polyclonal antibodies against cytochrome P-450IIB1/B2.

PubMed Disclaimer

References

    1. J Biol Chem. 1964 Jul;239:2379-85 - PubMed
    1. Mol Pharmacol. 1976 Nov;12(6):921-32 - PubMed
    1. Chem Biol Interact. 1986 Apr;58(1):57-68 - PubMed
    1. J Biol Chem. 1983 Jan 25;258(2):1282-8 - PubMed
    1. DNA. 1989 Jan-Feb;8(1):1-13 - PubMed