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. 2009 May 15;19(10):2731-4.
doi: 10.1016/j.bmcl.2009.03.120. Epub 2009 Mar 28.

Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents

Charles Francavilla  1 , Eddy Low, Satheesh Nair, Bum Kim, Timothy P Shiau, Dmitri Debabov, Chris Celeri, Nichole Alvarez, Ashley Houchin, Ping Xu, Ron Najafi, Rakesh Jain
Affiliations

Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents

Charles Francavilla et al. Bioorg Med Chem Lett. .

Abstract

A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.

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