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Review
. 2009 Mar;9(1):84-6.
doi: 10.3816/CLM.2009.n.022.

Novel therapeutic agents in Waldenström's macroglobulinemia

Irene M Ghobrial  1 , Xavier Leleu, Abdel Kareem Azab, Judith Runnels, Xiaoying Jia, Hai Ngo, Molly Melhem, Feda Azab, Antonio Sacco, Phong Quang, Nicholas Burwick, Anne-Sophie Moreau, Emanuel Husu, Mena Farag, Aldo Roccaro
Affiliations
Review

Novel therapeutic agents in Waldenström's macroglobulinemia

Irene M Ghobrial et al. Clin Lymphoma Myeloma. 2009 Mar.

Abstract

Within the past few years, major advances in the preclinical and clinical testing of novel therapeutic agents have occurred in Waldenström's macroglobulinemia (WM). These include agents that target the PI3K/Akt/mTOR pathway, PKC pathways, NF-kB signaling pathway, as well as tyrosine kinases and histone deacetylase inhibitors. In this review, we summarize the current understanding of the clinical development of these agents in WM.

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References

    1. Ghobrial IM, Gertz MA, Fonseca R. Waldenstrom macroglobulinaemia. Lancet Oncol. 2003;4:679–685. - PubMed
    1. Dimopoulos MA, Kyle RA, Anagnostopoulos A, et al. Diagnosis and management of Waldenstrom's macroglobulinemia. J Clin Oncol. 2005;23:1564–1577. - PubMed
    1. Treon SP, Dimopoulos M, Kyle RA. Defining Waldenstrom's macroglobulinemia. Semin Oncol. 2003;30:107–109. - PubMed
    1. Treon SP, Gertz MA, Dimopoulos M, et al. Update on treatment recommendations from the Third International Workshop on Waldenstrom’s macroglobulinemia. Blood. 2006;107:3442–3446. - PubMed
    1. Vijay A, Gertz MA. Waldenstrom Macroglobulinemia. Blood. 2007;109:5096–5103. - PubMed

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