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. 2009 Jan-Feb;10(1):48-51.
doi: 10.1310/hct1001-048.

Prevalence of HLA-B*5701 in HIV-infected patients in Spain (results of the EPI Study)

J Arrizabalaga  1 , F Rodriguez-Alcántara, J L Castañer, A Ocampo, D Podzamczer, F Pulido, M Riera, J Sanz, M Pascual-Bernaldez, R Dal-Re; EPI109839 Study Group
Collaborators, Affiliations

Prevalence of HLA-B*5701 in HIV-infected patients in Spain (results of the EPI Study)

J Arrizabalaga et al. HIV Clin Trials. 2009 Jan-Feb.

Abstract

Background: A hypersensitivity reaction (HSR) is associated with abacavir (ABC), a nucleoside reverse transcriptase inhibitor. Genetic association of ABC HSR with the presence of HLA-B*5701 has been demonstrated in PREDICT-1 study, showing a prevalence of 5.6% in HIV-infected population. However the prevalence of this allele in HIV-infected patients in Spain has not been established yet.

Method: This is a cross-sectional epidemiological study that included 1,198 patients in 74 centers that serve the HIV-infected population of Spain. HLA-B*5701 was checked both in the hospital lab and one central lab, showing an overall prevalence of this allele of 6%.

Results: HLA-B*5701 was most prevalent in Caucasian population (6.5%). Concordance between the local and central lab was very high for positive and negative results (95.7% and 99.3%, respectively).

Conclusion: These aspects define this test as a useful tool for the management of HIV-infected patients.

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