Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Apr:24:78-87.
doi: 10.1152/physiol.00041.2008.

AKAP-scaffolding proteins and regulation of cardiac physiology

J R H Mauban  1 , M O'Donnell, S Warrier, S Manni, M Bond
Affiliations
Review

AKAP-scaffolding proteins and regulation of cardiac physiology

J R H Mauban et al. Physiology (Bethesda). 2009 Apr.

Abstract

A kinase anchoring proteins (AKAPs) compose a growing list of diverse but functionally related proteins defined by their ability to bind to the regulatory subunit of protein kinase A. AKAPs perform an integral role in the spatiotemporal modulation of a multitude of cellular signaling pathways. This review highlights the extensive role of AKAPs in cardiac excitation/contraction coupling and cardiac physiology. The literature shows that particular AKAPs are involved in cardiac Ca(2+) influx, release, reuptake, and myocyte repolarization. Studies have also suggested roles for AKAPs in cardiac remodeling. Transgenic studies show functional effects of AKAPs, not only in the cardiovascular system but in other organ systems as well.

PubMed Disclaimer

Figures

Figure 1
Figure 1. AKAPs modulate cardiac excitation/contraction coupling
Different AKAPs are thought to be involved in the modulation of the cardiac action potential and Ca2+ transient. The processes of calcium entry via L-type calcium channels, calcium release from the sarcoplasmic reticulum via ryanodine receptors, calcium reuptake and cardiac repolarization employ AKAPs.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Altier C, Dubel SJ, Barrere C, Jarvis SE, Stotz SC, Spaetgens RL, Scott JD, Cornet V, De Waard M, Zamponi GW, Nargeot J, Bourinet E. Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. Journal of Biological Chemistry. 2002;277:33598–33603. - PubMed
    1. Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD. Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A. 2003;100:4445–4450. - PMC - PubMed
    1. Appert-Collin A, Cotecchia S, Nenniger-Tosato M, Pedrazzini T, Diviani D. The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 2007;104:10140–10145. - PMC - PubMed
    1. Beene DL, Scott JD. A-kinase anchoring proteins take shape. Curr Opin Cell Biol. 2007;19:192–198. - PMC - PubMed
    1. Bellin RM, Sernett SW, Becker B, Ip W, Huiatt TW, Robson RM. Molecular characteristics and interactions of the intermediate filament protein synemin. Interactions with alpha-actinin may anchor synemin-containing heterofilaments. Journal of Biological Chemistry. 1999;274:29493–29499. - PubMed

Publication types

Substances

LinkOut - more resources